Elevated RNA Editing Activity Is a Major Contributor to Transcriptomic Diversity in Tumors.

@article{PazYaacov2015ElevatedRE,
  title={Elevated RNA Editing Activity Is a Major Contributor to Transcriptomic Diversity in Tumors.},
  author={Nurit Paz-Yaacov and Lily Bazak and Ilana Buchumenski and Hagit T Porath and Miri Danan-Gotthold and Binyamin A Knisbacher and Eli Eisenberg and Erez Y. Levanon},
  journal={Cell reports},
  year={2015},
  volume={13 2},
  pages={267-76}
}
Genomic mutations in key genes are known to drive tumorigenesis and have been the focus of much attention in recent years. However, genetic content also may change farther downstream. RNA editing alters the mRNA sequence from its genomic blueprint in a dynamic and flexible way. A few isolated cases of editing alterations in cancer have been reported previously. Here, we provide a transcriptome-wide characterization of RNA editing across hundreds of cancer samples from multiple cancer tissues… CONTINUE READING
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Principles governing AtoI RNA editing in the breast cancer transcriptome

  • K. Y. Kim, S. Y. Park, D.-W. Lee, J.-K. Won, S.-Y. Jeong
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