Elevated Protein Carbonylation, and Misfolding in Sciatic Nerve from db/db and Sod1−/− Mice: Plausible Link between Oxidative Stress and Demyelination

Abstract

Diabetic peripheral polyneuropathy is associated with decrements in motor/sensory neuron myelination, nerve conduction and muscle function; however, the mechanisms of reduced myelination in diabetes are poorly understood. Chronic elevation of oxidative stress may be one of the potential determinants for demyelination as lipids and proteins are important… (More)
DOI: 10.1371/journal.pone.0065725

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Cite this paper

@inproceedings{Hamilton2013ElevatedPC, title={Elevated Protein Carbonylation, and Misfolding in Sciatic Nerve from db/db and Sod1−/− Mice: Plausible Link between Oxidative Stress and Demyelination}, author={Ryan T. Hamilton and Arunabh Bhattacharya and Michael E. Walsh and Yun Shi and Rochelle Wei and Yiqiang Zhang and Karl A. Rodriguez and Rochelle Buffenstein and Asish Ray Chaudhuri and Holly van Remmen}, booktitle={PloS one}, year={2013} }