Elevated Prolactin during Pregnancy Drives a Phenotypic Switch in Mouse Hypothalamic Dopaminergic Neurons.

@article{Yip2019ElevatedPD,
  title={Elevated Prolactin during Pregnancy Drives a Phenotypic Switch in Mouse Hypothalamic Dopaminergic Neurons.},
  author={Siew Hoong Yip and Nicola Roman{\`o} and Papillon Gustafson and David J Hodson and Eloise J Williams and Ilona C. Kokay and Agn{\`e}s O. Martin and Patrice Mollard and David R Grattan and Stephen J Bunn},
  journal={Cell reports},
  year={2019},
  volume={26 7},
  pages={
          1787-1799.e5
        }
}
Altered physiological states require neuronal adaptation. In late pregnancy and lactation, a sub-population of the mouse hypothalamic tuberoinfundibular dopaminergic (TIDA) neurons alters their behavior to synthesize and release met-enkephalin rather than dopamine. These neurons normally release dopamine to inhibit prolactin secretion and are activated by prolactin in a short-loop feedback manner. In lactation, dopamine synthesis is suppressed in an opioid-dependent (naloxone-reversible) manner… CONTINUE READING
5
Twitter Mentions

References

Publications referenced by this paper.
SHOWING 1-10 OF 53 REFERENCES

Plasticity of hypothalamic dopamine neurons during lactation results in dissociation of electrical activity and release.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2013
VIEW 12 EXCERPTS