Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes.

@article{Gonalves2015ElevatedPL,
  title={Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes.},
  author={I. Gonçalves and Eva Lena Bengtsson and Helen M. Colhoun and Angela C. Shore and Carlo Palombo and Andrea Natal{\'i} and Andreas Edsfeldt and Pontus Dun{\'e}r and Gunilla Nordin Fredrikson and Harry Bj{\"o}rkbacka and Gerd {\"O}stling and Kunihiko Aizawa and Francesco Casanova and Margaretha Persson and Kim Gooding and David W Strain and Faisel Khan and Helen C. Looker and Fiona Adams and Jill J. F. Belch and Silvia Pinnoli and Elena Venturi and Michaela Koz{\'a}kov{\'a} and Li-Ming Gan and Volker Schnecke and Jan Nilsson},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2015},
  volume={35 7},
  pages={
          1723-31
        }
}
OBJECTIVE Matrix metalloproteinases (MMPs) degrade extracellular matrix proteins and play important roles in development and tissue repair. They have also been shown to have both protective and pathogenic effects in atherosclerosis, and experimental studies have suggested that MMP-12 contributes to plaque growth and destabilization. The objective of this study was to investigate the associations between circulating MMPs, atherosclerosis burden, and incidence of cardiovascular disease with a… CONTINUE READING

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