Elevated Non-Esterified Fatty Acid Concentrations during Bovine Oocyte Maturation Compromise Early Embryo Physiology

@article{VanHoeck2011ElevatedNF,
  title={Elevated Non-Esterified Fatty Acid Concentrations during Bovine Oocyte Maturation Compromise Early Embryo Physiology},
  author={Veerle Van Hoeck and Roger G Sturmey and Pablo Bermejo-{\'A}lvarez and Dimitrios Rizos and Alfonso Guti{\'e}rrez-Ad{\'a}n and Henry J. Leese and Peter E. J. Bols and Jo L.M.R. Leroy},
  journal={PLoS ONE},
  year={2011},
  volume={6}
}
Elevated concentrations of serum non-esterified fatty acids (NEFA), associated with maternal disorders such as obesity and type II diabetes, alter the ovarian follicular micro-environment and have been associated with subfertility arising from reduced oocyte developmental competence. We have asked whether elevated NEFA concentrations during oocyte maturation affect the development and physiology of zygotes formed from such oocytes, using the cow as a model. The zygotes were grown to blastocysts… Expand
Oocyte developmental failure in response to elevated nonesterified fatty acid concentrations: mechanistic insights.
TLDR
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TLDR
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TLDR
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Interaction between differential gene expression profile and phenotype in bovine blastocysts originating from oocytes exposed to elevated non-esterified fatty acid concentrations.
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Bovine Cumulus Cells Protect Maturing Oocytes from Increased Fatty Acid Levels by Massive Intracellular Lipid Storage1
TLDR
It is proposed that the involvement of high levels of mobilized oleic acid in follicular fluid in combination with the induced lipid storage in cumulus cells serves to prevent harmful saturated fatty acid exposure to the oocyte. Expand
Fatty acid induced lipolysis influences embryo development, gene expression and lipid droplet formation in the porcine cumulus cells†
TLDR
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Lipids and oocyte developmental competence: the role of fatty acids and β-oxidation.
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Nonesterified Fatty Acid-Induced Endoplasmic Reticulum Stress in Cattle Cumulus Oocyte Complexes Alters Cell Metabolism and Developmental Competence1
TLDR
The significance of NEFA-induced ER stress on bovine COC developmental competence is revealed, revealing a potential therapeutic target for improving oocyte quality during peak lactation. Expand
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