Elevated Na/H exchanger 1 (SLC9A1) emerges as a marker for tumorigenesis and prognosis in gliomas

@inproceedings{Guan2018ElevatedNE,
  title={Elevated Na/H exchanger 1 (SLC9A1) emerges as a marker for tumorigenesis and prognosis in gliomas},
  author={Xiudong Guan and Lanxin Luo and Gulnaz Begum and Gary Kohanbash and Qingkun Song and Aparna V. S. Rao and Nduka M. Amankulor and Baoshan Sun and Dandan Sun and Wang Jia},
  booktitle={Journal of experimental & clinical cancer research : CR},
  year={2018}
}
BackgroundSodium/hydrogen exchanger 1 (NHE1), encoded by the SLC9A1 gene (SoLute Carrier family 9A1) in humans, is the main H+ efflux mechanism in maintaining alkaline intracellular pH (pHi) and Warburg effects in glioma. However, to date, there are no clinical studies exploring pharmacological inhibition of NHE1 protein in cancer treatment. In this study, we investigated NHE1 expression in gliomas and its relationship with glioma clinical outcome.MethodsThe Chinese Glioma Genome Atlas (CGGA… CONTINUE READING
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