Elevated Mitochondrial Bioenergetics and Axonal Arborization Size Are Key Contributors to the Vulnerability of Dopamine Neurons

@article{Pacelli2015ElevatedMB,
  title={Elevated Mitochondrial Bioenergetics and Axonal Arborization Size Are Key Contributors to the Vulnerability of Dopamine Neurons},
  author={Consiglia Pacelli and Nicolas Gigu{\`e}re and Marie-Jos{\'e}e Bourque and Martin L{\'e}vesque and Ruth S Slack and L. C. Trudeau},
  journal={Current Biology},
  year={2015},
  volume={25},
  pages={2349-2360}
}
Although the mechanisms underlying the loss of neurons in Parkinson's disease are not well understood, impaired mitochondrial function and pathological protein aggregation are suspected as playing a major role. Why DA (dopamine) neurons and a select small subset of brain nuclei are particularly vulnerable to such ubiquitous cellular dysfunctions is presently one of the key unanswered questions in Parkinson's disease research. One intriguing hypothesis is that their heightened vulnerability is a… CONTINUE READING
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References

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Showing 1-10 of 59 references

Cross-talk between L-type Ca2+ channels and mitochondria.

Clinical and experimental pharmacology & physiology • 2010
View 16 Excerpts
Highly Influenced

a 2015 Els during midbrain dopaminergic neuron development

J. A. Mendez, M.-J. Bourque, +5 authors L.-E. Trudeau
J . Neurochem . • 2015

Calcium entry and α-synuclein inclusions elevate dendritic mitochondrial oxidant stress in dopaminergic neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2013
View 1 Excerpt

The transcription factor Pitx3 is expressed selectively in midbrain dopaminergic neurons susceptible to neurodegenerative stress

K. C. Luk, V. V. Rymar, +5 authors A. F. Sadikot
J. Neurochem • 2013
View 2 Excerpts

Living on the edge with too many mouths to feed: Why dopamine neurons die

Movement disorders : official journal of the Movement Disorder Society • 2012
View 3 Excerpts

Mitochondrial biology and Parkinson's disease.

Cold Spring Harbor perspectives in medicine • 2012
View 1 Excerpt

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