Elevated MMP-9 in the lumbar cord early after thoracic spinal cord injury impedes motor relearning in mice.

@article{Hansen2013ElevatedMI,
  title={Elevated MMP-9 in the lumbar cord early after thoracic spinal cord injury impedes motor relearning in mice.},
  author={Christopher N. Hansen and Lesley C. Fisher and Rochelle J Deibert and Lyn B. Jakeman and Haoqian M Zhang and L J Noble-Haeusslein and Susan F White and Daniel M. Basso},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2013},
  volume={33 32},
  pages={13101-11}
}
Spinal cord injury results in distant pathology around putative locomotor networks that may jeopardize the recovery of locomotion. We previously showed that activated microglia and increased cytokine expression extend at least 10 segments below the injury to influence sensory function. Matrix metalloproteinase-9 (MMP-9) is a potent regulator of acute neuroinflammation. Whether MMP-9 is produced remote to the injury or influences locomotor plasticity remains unexamined. Therefore, we… CONTINUE READING
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