Elevated IgG antibody levels to the mycobacterial 65-kDa heat shock protein are characteristic of patients with rheumatoid arthritis.

@article{Tsoulfa1989ElevatedIA,
  title={Elevated IgG antibody levels to the mycobacterial 65-kDa heat shock protein are characteristic of patients with rheumatoid arthritis.},
  author={G Tsoulfa and Graham A. W. Rook and George M. Bahr and Mehana A. Sattar and Kazem Behbehani and Douglas Brownlee Young and Angela Mehlert and J D Van-Embden and Frank C. Hay and David Alan Isenberg},
  journal={Scandinavian journal of immunology},
  year={1989},
  volume={30 5},
  pages={519-27}
}
We have previously demonstrated raised levels of IgG and IgA antibody to the mycobacterial 65-kDa heat shock protein (hsp) in the sera of patients with rheumatoid arthritis (RA). We have now attempted to determine whether this phenomenon is specific for RA, and whether it is seen only with the mycobacterial homologue of this particular hsp gene family. We therefore screened antibody levels to the mycobacterial and Escherichia coli hsp 65, and the mycobacterial, E. coli, and human hsp70, in sera… CONTINUE READING

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