Elevated IL-17 produced by TH17 cells promotes myeloma cell growth and inhibits immune function in multiple myeloma.

@article{Prabhala2010ElevatedIP,
  title={Elevated IL-17 produced by TH17 cells promotes myeloma cell growth and inhibits immune function in multiple myeloma.},
  author={Rao H. Prabhala and Dheeraj Pelluru and Mariateresa T Fulciniti and Harsha Kiran Prabhala and Puru Nanjappa and Weihua Song and Christine Pai and Samir Amin and Yu-Tzu Tai and Paul G Richardson and Irene M Ghobrial and Steven P Treon and John F. Daley and Kenneth C. Anderson and Jeffery L. Kutok and Nikhil C. Munshi},
  journal={Blood},
  year={2010},
  volume={115 26},
  pages={5385-92}
}
Elevated cytokines in bone marrow (BM) micro-environment (interleukin-6 [IL-6], transforming growth factor-beta [TGF-beta], and IL-1beta) may play an important role in observed immune dysfunction in multiple myeloma (MM). As IL-6 and TGF-beta are important for the generation of T-helper 17 (T(H)17) cells, we evaluated and observed a significantly elevated baseline and induced frequency of T(h)17 cells in peripheral blood mononuclear cells (PBMCs) and BM mononuclear cells (BMMCs) from MM… CONTINUE READING