Elevated IGF-II mRNA and phosphorylation of 4E-BP1 and p70(S6k) in muscle showing clenbuterol-induced anabolism.

@article{Sneddon2001ElevatedIM,
  title={Elevated IGF-II mRNA and phosphorylation of 4E-BP1 and p70(S6k) in muscle showing clenbuterol-induced anabolism.},
  author={Alan A. Sneddon and Margaret I. Delday and J Reynolds Steven and Charlotte Maltin},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2001},
  volume={281 4},
  pages={E676-82}
}
Muscle wasting affects large numbers of people, but few therapeutic approaches exist to treat and/or reverse this condition. The beta(2)-adrenoceptor agonist clenbuterol produces a muscle-specific protein anabolism in both normal and catabolic muscle and has been used to limit muscle wasting in humans. Because clenbuterol appears to interact with or mimic innervation, its effect on the expression of the neurotrophic agents insulin-like growth factor (IGF)-II and H19 and their putative pathways… CONTINUE READING
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A study of the conditions and mechanisms of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid

  • K. Burton
  • Biochem J
  • 1956
Highly Influential
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