Elevated Expression of the Tumor Suppressing Protein p53 is Associated with the Presence of Mouse Mammary Tumor-Like env Gene Sequences (MMTV-like) in Human Breast Cancer

@article{Lawson2004ElevatedEO,
  title={Elevated Expression of the Tumor Suppressing Protein p53 is Associated with the Presence of Mouse Mammary Tumor-Like env Gene Sequences (MMTV-like) in Human Breast Cancer},
  author={James S Lawson and Dinh Dac Tran and Caroline S Ford and William D Rawlinson},
  journal={Breast Cancer Research and Treatment},
  year={2004},
  volume={87},
  pages={13-17}
}
Mouse mammary tumor virus (MMTV) has a proven role in breast carcinogenesis in wild mice and genetically susceptible laboratory inbred mice. The carcinogenic characteristics of this virus are enhanced by estrogen and other steroid hormones. MMTV-like envelope gene sequences, with 95% homology to MMTV have been identified in approximately 40% of breast cancers in US, Australian and Argentinian women. The presence of such sequences indicates the presence of a replication competent MMTV-like virus… CONTINUE READING

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