Elevated DNase I levels in human idiopathic dilated cardiomyopathy: an indicator of apoptosis?

@article{Yao1996ElevatedDI,
  title={Elevated DNase I levels in human idiopathic dilated cardiomyopathy: an indicator of apoptosis?},
  author={Minghua Yao and Anne Keogh and Phillip Spratt and Cristobal G Dos Remedios and Peter C. Kiessling},
  journal={Journal of molecular and cellular cardiology},
  year={1996},
  volume={28 1},
  pages={95-101}
}
This is the first report to determine deoxyribonuclease I (DNase I) levels in the human myocardium and the first to demonstrate an increased DNase I level associated with end-stage heart failure due to idiopathic dilated cardiomyopathy (IDCM) compared to non-diseased heart samples. Left ventricular samples were obtained following transplantation from failing hearts of 13 patients diagnosed with IDCM and from four unused donor hearts. Using a zymogram technique, we show that the DNase I levels… CONTINUE READING
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