Elevated CSF CRF in suicide victims

  title={Elevated CSF CRF in suicide victims},
  author={Mih{\^a}ly Arat{\^o} and Csaba M. B{\'a}nki and Garth Bissette and Charles B. Nemeroff},
  journal={Biological Psychiatry},

The dexamethasone suppression test in violent suicide attempters with major depression

The dexamethasone suppression test and suicide prediction.

In efforts to predict and prevent suicidal behavior in patients with major depressive disorder, HPA-axis hyperactivity, as reflected in DST results, may provide a tool that is considerably more powerful than the clinical predictors currently in use.

The role of Corticotropin Releasing Factor in Depressive Illness: a Critical Review

  • A. Mitchell
  • Psychology, Biology
    Neuroscience & Biobehavioral Reviews
  • 1998

Hyperactivity of the hypothalamic–pituitary–adrenal axis and mortality in major depressive disorder

Suicide as an indicium of biologically-based brain disease

Abstract Neurobiological evidence indicates that more than mood disorders, impulsive self-directed and other-directed violence and associated behaviors resistent to impulse control are biologically

Elevated Concentrations of CRF in the Locus Coeruleus of Depressed Subjects

Increased concentrations of CRF-like immunoreactivity in micropunches of post-mortem LC from subjects with MDD symptoms as established by retrospective psychiatric diagnosis compared to nondepressed subjects matched for age and sex are described.

The role of corticotropin-releasing factor in depression and anxiety disorders.

The hypothesis that CRF receptor antagonists may represent a novel class of antidepressants and/or anxiolytics, probably through its effects on central noradrenergic systems, is supported.



Biochemistry and suicidal behavior in depressed patients

Relationship to Suicidal Behavior

Results of two additional investigations of relationships between suicidal behavior and HPA axis are summarized to relate these findings to results of prior studies, and to discuss practical and theoretical implications.

Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients.

Findings are concordant with the hypothesis that CRF hypersecretion is, at least in part, responsible for the hyperactivity of the hypothalamo-pituitary-adrenal axis characteristic of major depression.

CSF corticotropin-releasing factor-like immunoreactivity in depression and schizophrenia.

The authors measured CRF-like immunoreactivity in CSF samples from 138 neurological control, 54 depressed, and 27 nondepressed patients to provide further support for the hypothesis that CRF hypersecretion occurs in major depression.

Hypothalamic‐Pituitary‐Adrenal Axis and Suicide

One interpretation, the activated HPA may reflect a disturbance of limbic-hypothalamic monoamine metabolism, something that has been implicated in the pathophysiology of affective disorders.

The Dexamethasone Suppression Test and Suicidal Patients

The poor specificity of the DST in this patient population suggests that its routine use in such patients could be highly misleading.

The dexamethasone suppression test in depression.

The Dexamethasone Suppression Test (DST) was performed in 91 patients (depressive, manic and schizophrenic) and 11 healthy control persons. It was found that more endogenously depressed patients than

Dexamethasone suppression test (DST) in relation to depressive somatic and suicidal manifestations

ABSTRACT— An investigation of 51 depressed inpatients showed a significant positive correlation between non‐suppression in dexamethasone suppression test (DST) and the extent of depressive somatic