Elevated ATF4 expression, in the absence of other signals, is sufficient for transcriptional induction via CCAAT enhancer-binding protein-activating transcription factor response elements.

@article{Shan2009ElevatedAE,
  title={Elevated ATF4 expression, in the absence of other signals, is sufficient for transcriptional induction via CCAAT enhancer-binding protein-activating transcription factor response elements.},
  author={Jixiu Shan and Daima Ord and T{\~o}nis Ord and Michael S. Kilberg},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 32},
  pages={21241-8}
}
Protein limitation in vivo or amino acid deprivation of cells in culture causes a signal transduction cascade consisting of activation of the kinase GCN2 (general control nonderepressible 2), phosphorylation of eukaryotic initiation factor 2, and increased synthesis of activating transcription factor (ATF) 4 by a translational control mechanism. In a self-limiting transcriptional program, ATF4 transiently activates a wide range of downstream target genes involved in transport, cellular… CONTINUE READING

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