Elevated 4-hydroxyhexenal in Alzheimer's disease (AD) progression.

  title={Elevated 4-hydroxyhexenal in Alzheimer's disease (AD) progression.},
  author={Melissa A. Bradley and Shuling Xiong-Fister and William R. Markesbery and Mark A Lovell},
  journal={Neurobiology of aging},
  volume={33 6},
Multiple studies have demonstrated elevations of α, β-unsaturated aldehydes including 4-hydroxynonenal (HNE) and acrolein, in vulnerable regions of mild cognitive impairment (MCI), preclinical Alzheimer's disease (PCAD), and late stage Alzheimer's disease (LAD) brain. However, there has been limited study of a third member, 4-hydroxyhexenal (HHE), a diffusible lipid peroxidation product of the ω-3 polyunstataturated fatty acids (PUFAs). In the present study levels of extractable and protein… CONTINUE READING