• Corpus ID: 56208057

Eleutherococcus senticosus as a crude medicine: Review of biological and pharmacological effects

  title={Eleutherococcus senticosus as a crude medicine: Review of biological and pharmacological effects},
  author={Sun Yan-lin and Liu Lin-de and Hong Soon-Kwan},
  journal={Journal of Medicinal Plants Research},
Eleutherococcus senticosus (Rupr. et Maxim.) Harms (Acanthopanax senticosus, Araliaceae, ES, thereafter), also called Siberian ginseng, Ciwujia in Chinese, and Gasiogalpi in Korea, is distributed in the southeastern Russia, northeast China, Korea, and Japan. The woody medicinal plant has been known since ancient times for its curative properties, and particularly the cortical roots and stem tissues of ES have been utilized for the treatment of various ailments such as cancer, diabetes… 
Eleutherococcus senticosus: studies and effects.
The purpose of this article is to describe the main, adverse and toxicological effects of Eleutherococcus senticosus recently related in the literature.
Composition, antioxidant and antimicrobial activities of Eleutherococcus senticosus fruit extracts
Results suggest that Siberian ginseng fruit may be a good candidate as a source of antioxidant and antimicrobial ingredients.
Eleutheroside E, an active compound from Eleutherococcus senticosus, regulates adipogenesis in 3T3-L1 cells
This is the first report of an anti-adipogenic effect of E. senticosus and the active compound eleutheroside E, responsible for the pharmacological anti- adipogenic effects via regulation of the mTOR pathway.
Cytotoxic activity of ethanolic extracts of Eleutherococcus species cultivated in Poland on HL60 leukemia cell line
The ethanol extract from the roots of E. divaricatus showed the highest cytotoxic and proapoptotic effect on HL60 human lymphoid leukemia cell line, and the anti-leukemic potential of roots and leaves from six Eleutherococcus species cultivated in Poland was determined.
Biological activity of selected plants with adaptogenic effect
The aim of this study was to determine biological activity of plants with adaptogenic effect: Panax ginseng Mayer., Withania somnifera L., Eleuterococcus senticosus Rupr. et Maxim., Astragallus
A comprehensive in silico exploration of pharmacological properties, bioactivities and COX-2 inhibitory potential of eleutheroside B from Eleutherococcus senticosus (Rupr. & Maxim.) Maxim.
This study suggests that eleutheroside B is a drug-like compound with bioactivity score (-0.08 to 0.38), having satisfactory pharmacokinetic values, and can be utilized as an anti-inflammatory agent as well as a potential anticancer drug in the future.
Comparison between the Biological Active Compounds in Plants with Adaptogenic Properties (Rhaponticum carthamoides, Lepidium meyenii, Eleutherococcus senticosus and Panax ginseng)
There is great potential in the near future for some of the phytochemicals found in these plants species to become pharmaceutical agents.
Production of Bioactive Compounds from Somatic Embryo Suspension Cultures of Siberian Ginseng in Bioreactors
This review has presented bioreactor scale production of bioactive compounds and explained various bioprocess strategies for the production of eleutheroside B, E, E1 and chlorogenic acid.
Root growth of Eleuthero (Eleutherococcus senticosus [Rupr. & Maxim.] Maxim.) seedlings cultured with chitosan oligosaccharide addition under different light spectra
Eleuthero (Eleutherococcus senticosus [Ruprecht & Maximowicz] Maximowicz is an important understory species as well as a source of natural products in Asia. The natural source of Eleuthero has been
Genotoxicity Study from the Extracts of Fermented Acanthopanax koreanum
The results suggest that the extracts of fermented A. koreanum did not induce any harmful genotoxic effects.


Acanthopanax senticosus: review of botany, chemistry and pharmacology.
The present review is an up-to-date and comprehensive analysis of the botany, chemistry, pharmacology, toxicity and clinical trials of Acanthopanax senticosus.
Constituents and pharmacological effects of Eucommia and Siberian ginseng.
The bark and leaves of Eucommia ulmoides Oliv (Eucommiaceae) and "Siberian ginseng" (Ezoukogi in Japanese) prepared from the root bark or stem bark of Eleutherococcus senticosus Maxim have been used as tonic and anti-stress drug and their pharmacological activities were mainly due to lignans and iridoid glycosides.
Effects of Eleutherococcus senticosus and Several Oriental Medicinal Herbs Extracts on Serum Lipid Concentrations
The results imply that combination of several medicinal herbal extracts could be used to reduce of serum lipid concentrations in rats fed a high-fat diet for 5 weeks.
Anti-oxidant activities ofacanthopanax senticosus stems and their lignan components
The antioxidant activities of Canthopanax senticosus stems were evaluated in CCI4-intoxicated rats and suggested that the stems of A. senticOSus possess not only antioxidant but also hepatoprotective activities.
Antimutagenic Effect of Extract of Eleutherococcus senticosus Maxim
Results suggest that the methanol extract of E. senticosus inhibits a frame shift mutation in Salmonella typhimurium TA98, which is a dose-dependent manner and may be responsible for the mutagenicity of the latter.
Water-soluble polysaccharide from Eleutherococcus senticosus stems attenuates fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide in mice.
Results indicate E. senticosus stems attenuate fulminant hepatic failure induced by D-galactosamine/lipopolysaccharide in mice and the protective effect is due to water-soluble polysaccharides in E. sendicosUS stems.
Protective effects of Acanthopanax senticosus Harms from Hokkaido and its components on gastric ulcer in restrained cold water stressed rats.
It is suggested that the protective effect of the stem bark of A. senticosus on gastric ulcer may be partially due to those of chlorogenic acid and syringaresinol di-o-beta-D-glucoside.
Enfluence of Herbal Extract on Lactic Acid Bacteria Growth and Cryoprotectants
During accelerated storage of freeze-dried lactic acid bacteria, those survival rate decrease rapidly, reaching 8 -18% in one month, but addition of Eleutherococcus senticosus extract in freeze dry of L. acidophilus showed a positive activity in storage.
Estimation of humoral activity of Eleutherococcus senticosus.
The aim of the present work was an estimation of the influence of two plant pharmaceutical preparations containing an extract from the root of Eleutherococcus senticosus: Argoeleuter tablets and