Elements of regiocontrol in palladium-catalyzed oxidative arene cross-coupling.

  title={Elements of regiocontrol in palladium-catalyzed oxidative arene cross-coupling.},
  author={David R Stuart and Elisia Villemure and Keith Fagnou},
  journal={Journal of the American Chemical Society},
  volume={129 40},
An increasing emphasis on waste minimization has prompted research aimed at replacing common synthetic techniques with greener alternatives. In biaryl synthesis, direct arylation 1,2 is an emerging alternative to Suzuki and Stille couplings; 3 however, a more efficient strategy would involve the direct catalytic crosscoupling of two arenes without recourse to stoichiometric activating groups (eq 1). 4-7 This last approach presents several new challenges, 

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For illustrative recent examples employing metal oxidants

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For recent examples of oxidative arene homocoupling

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For lead examples dealing with oxidative cross-coupling and stoichiometric Pd, see: (a) Itahara, T

  • X. Li, J. B. Hewgley, C. A. Mulrooney, J. Yang, M.C.J. Kozlowski
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