Elements distinct from human immunodeficiency virus type 1 splice sites are responsible for the Rev dependence of env mRNA.

@article{Nasioulas1994ElementsDF,
  title={Elements distinct from human immunodeficiency virus type 1 splice sites are responsible for the Rev dependence of env mRNA.},
  author={George Nasioulas and Andrei S. Zolotukhin and C Tabernero and Ludmila Solomin and Craig P. Cunningham and George N Pavlakis and Barbara K Felber},
  journal={Journal of virology},
  year={1994},
  volume={68 5},
  pages={2986-93}
}
In the absence of the viral regulatory protein Rev, the human immunodeficiency virus type 1 gag/pol and env mRNAs are inefficiently expressed, since nucleocytoplasmic transport, stability, and polysomal loading are impaired. It has been suggested that splicing is necessary for Rev function and that the low expression of the unspliced and intermediate spliced mRNAs in the absence of Rev is associated with specific splice sites. Previous studies identified distinct RNA elements within the gag/pol… CONTINUE READING

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