Elementary steps of proton translocation in the catalytic cycle of cytochrome oxidase.

@article{Verkhovsky2006ElementarySO,
  title={Elementary steps of proton translocation in the catalytic cycle of cytochrome oxidase.},
  author={Michael I. Verkhovsky and Ilya Belevich and Dmitry A. Bloch and M{\aa}rten Wikstr{\"o}m},
  journal={Biochimica et biophysica acta},
  year={2006},
  volume={1757 5-6},
  pages={401-7}
}
Proton translocation in the catalytic cycle of cytochrome c oxidase (CcO) proceeds sequentially in a four-stroke manner. Every electron donated by cytochrome c drives the enzyme from one of four relatively stable intermediates to another, and each of these transitions is coupled to proton translocation across the membrane, and to uptake of another proton for production of water in the catalytic site. Using cytochrome c oxidase from Paracoccus denitrificans we have studied the kinetics of… CONTINUE READING

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