Elementary properties and pharmacological sensitivities of calcium channels in mammalian peripheral neurons.

@article{Plummer1989ElementaryPA,
  title={Elementary properties and pharmacological sensitivities of calcium channels in mammalian peripheral neurons.},
  author={Mark R. Plummer and Diomedes E. Logothetis and Peter Hess},
  journal={Neuron},
  year={1989},
  volume={2 5},
  pages={1453-63}
}
The major component of whole-cell Ca2+ current in differentiated, neuron-like rat pheochromocytoma (PC12) cells and sympathetic neurons is carried by dihydropyridine-insensitive, high-threshold-activated N-type Ca2+ channels. We show that these channels have unitary properties distinct from those of previously described Ca2+ channels and contribute both slowly inactivating and large sustained components of whole-cell current. The N-type Ca2+ currents are modulated by GTP binding proteins. The… CONTINUE READING
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