Elemental signals regulating eosinophil accumulation in the lung.

  title={Elemental signals regulating eosinophil accumulation in the lung.},
  author={Paul S Foster and Arne W Mould and Ming Yang and Joanne Mackenzie and Joerg Mattes and Simon P Hogan and Surendran Mahalingam and Andrew N. J. McKenzie and Marc E Rothenberg and Ian G. Young and Klaus Ingo Matthaei and Dianne C. Webb},
  journal={Immunological reviews},
In this review we identify the elemental signals that regulate eosinophil accumulation in the allergic lung. We show that there are two interwoven mechanisms for the accumulation of eosinophils in pulmonary tissues and that these mechanisms are linked to the development of airways hyperreactivity (AHR). Interleukin-(IL)-5 plays a critical role in the expansion of eosinophil pools in both the bone marrow and blood in response to allergen provocation of the airways. Secondly, IL-4 and IL-13… CONTINUE READING


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