Electrotransfer of naked DNA in the skeletal muscles of animal models of muscular dystrophies

@article{Vilquin2001ElectrotransferON,
  title={Electrotransfer of naked DNA in the skeletal muscles of animal models of muscular dystrophies},
  author={JT Vilquin and P F Kennel and Marion Paturneau-Jouas and P. Anthony Chapdelaine and Nicolas Boissel and Pia Dela{\`e}re and JP Tremblay and Daniel Scherman and Marc Fiszman and Ketty Schwartz},
  journal={Gene Therapy},
  year={2001},
  volume={8},
  pages={1097-1107}
}
The electrotransfer of naked DNA has recently been adapted to the transduction of skeletal muscle fibers. We investigated the short- and long-term efficacy of this methodology in wild-type animals and in mouse models of congenital muscular dystrophy (dy/dy, dy2J/dy2J), or Duchenne muscular dystrophy (mdx/mdx). Using a reporter construct, the short-term efficacy of fiber transduction reached 40% and was similar in wild-type, dy/dy and dy2J/dy2J animals, indicating that ongoing muscle fibrosis… CONTINUE READING
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