Electrotransfer of naked DNA in the skeletal muscles of animal models of muscular dystrophies

@article{Vilquin2001ElectrotransferON,
  title={Electrotransfer of naked DNA in the skeletal muscles of animal models of muscular dystrophies},
  author={J.-T. Vilquin and P Kennel and Marion Paturneau-Jouas and Pierre Chapdelaine and Nicolas Boissel and Pia Dela{\`e}re and J. P. Tremblay and Daniel Scherman and M Fiszman and Ketty Schwartz},
  journal={Gene Therapy},
  year={2001},
  volume={8},
  pages={1097-1107}
}
The electrotransfer of naked DNA has recently been adapted to the transduction of skeletal muscle fibers. We investigated the short- and long-term efficacy of this methodology in wild-type animals and in mouse models of congenital muscular dystrophy (dy/dy, dy2J/dy2J), or Duchenne muscular dystrophy (mdx/mdx). Using a reporter construct, the short-term efficacy of fiber transduction reached 40% and was similar in wild-type, dy/dy and dy2J/dy2J animals, indicating that ongoing muscle fibrosis… Expand
Electrotransfer of the full-length dog dystrophin into mouse and dystrophic dog muscles.
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  • D. Wells
  • Biology, Medicine
  • Journal of Muscle Research & Cell Motility
  • 2006
TLDR
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TLDR
A proof of concept of IMEP model usefulness for the rapid screening of therapeutic strategies, as demonstrated using antisense oligonucleotides against DUX4 mRNA. Expand
Amphiphilic block copolymers promote gene delivery in vivo to pathological skeletal muscles.
TLDR
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TLDR
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