Electrotransfer of naked DNA in the skeletal muscles of animal models of muscular dystrophies

  title={Electrotransfer of naked DNA in the skeletal muscles of animal models of muscular dystrophies},
  author={J.-T. Vilquin and P. Kennel and M. Paturneau-Jouas and P. Chapdelaine and N. Boissel and P. Delaere and JP Tremblay and D. Scherman and My Fiszman and K. Schwartz},
  journal={Gene Therapy},
  • J.-T. Vilquin, P. Kennel, +7 authors K. Schwartz
  • Published 2001
  • Biology, Medicine
  • Gene Therapy
  • The electrotransfer of naked DNA has recently been adapted to the transduction of skeletal muscle fibers. We investigated the short- and long-term efficacy of this methodology in wild-type animals and in mouse models of congenital muscular dystrophy (dy/dy, dy2J/dy2J), or Duchenne muscular dystrophy (mdx/mdx). Using a reporter construct, the short-term efficacy of fiber transduction reached 40% and was similar in wild-type, dy/dy and dy2J/dy2J animals, indicating that ongoing muscle fibrosis… CONTINUE READING
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