Electrotonic modulation of cardiac impulse conduction by myofibroblasts.

  title={Electrotonic modulation of cardiac impulse conduction by myofibroblasts.},
  author={Michele Miragoli and Giedrius Gaudesius and Stephan Rohr},
  journal={Circulation research},
  volume={98 6},
Structural remodeling of the myocardium associated with mechanical overload or cardiac infarction is accompanied by the appearance of myofibroblasts. These fibroblast-like cells express alpha-smooth muscle actin (alphaSMA) and have been shown to express connexins in tissues other than heart. The present study examined whether myofibroblasts of cardiac origin establish heterocellular gap junctional coupling with cardiomyocytes and whether ensuing electrotonic interactions affect impulse… CONTINUE READING
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