Electrostatics and the Gating Pore of Shaker Potassium Channels

@article{Islas2001ElectrostaticsAT,
  title={Electrostatics and the Gating Pore of Shaker Potassium Channels},
  author={Le{\'o}n D Islas and Fred J. Sigworth},
  journal={The Journal of General Physiology},
  year={2001},
  volume={117},
  pages={69 - 90}
}
Various experiments have suggested that the S4 segment in voltage-dependent Na(+) and K(+) channels is in contact with a solvent-accessible cavity. We explore the consequences of the existence of such a cavity through the electrostatic effects on the gating currents of Shaker K(+) channels under conditions of reduced ionic strength S. We observe that approximately 10-fold reductions of intracellular S produce reductions of the measured gating charge of approximately 10%. These effects continue… CONTINUE READING
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