Electrostatic readout of DNA microarrays with charged microspheres

@article{Clack2008ElectrostaticRO,
  title={Electrostatic readout of DNA microarrays with charged microspheres},
  author={Nathan G. Clack and Khalid Salaita and Jay T. Groves},
  journal={Nature Biotechnology},
  year={2008},
  volume={26},
  pages={825-830}
}
DNA microarrays are used for gene-expression profiling, single-nucleotide polymorphism detection and disease diagnosis. A persistent challenge in this area is the lack of microarray screening technology suitable for integration into routine clinical care. Here, we describe a method for sensitive and label-free electrostatic readout of DNA or RNA hybridization on microarrays. The electrostatic properties of the microarray are measured from the position and motion of charged microspheres randomly… CONTINUE READING
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