Electrostatic control of proton pumping in cytochrome c oxidase.

  title={Electrostatic control of proton pumping in cytochrome c oxidase.},
  author={Elisa Fadda and Ching-Hsing Yu and R{\'e}gis Pom{\`e}s},
  journal={Biochimica et biophysica acta},
  volume={1777 3},
As part of the mitochondrial respiratory chain, cytochrome c oxidase utilizes the energy produced by the reduction of O2 to water to fuel vectorial proton transport. The mechanism coupling proton pumping to redox chemistry is unknown. Recent advances have provided evidence that each of the four observable transitions in the complex catalytic cycle consists of a similar sequence of events. However, the physico-chemical basis underlying this recurring sequence has not been identified. We identify… CONTINUE READING

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