Electrostatic control of aromatic stacking interactions.

  title={Electrostatic control of aromatic stacking interactions.},
  author={Scott L Cockroft and Christopher A. Hunter and Kevin Lawson and Julie Perkins and Christopher J Urch},
  journal={Journal of the American Chemical Society},
  volume={127 24},
A supramolecular approach has been used to investigate the free energies of intermolecular aromatic stacking interactions. Chemical double mutant cycles have been used to measure the effect of a range of substituents on face-to-face stacking interactions with phenyl and pentafluorophenyl rings. Electrostatic effects dominate the trends in interaction energy.