Electrostatic contributions to heat capacity changes of DNA-ligand binding.

@article{Gallagher1998ElectrostaticCT,
  title={Electrostatic contributions to heat capacity changes of DNA-ligand binding.},
  author={Kelly Ryan Gallagher and Kim Sharp},
  journal={Biophysical journal},
  year={1998},
  volume={75 2},
  pages={769-76}
}
Significant heat capacity changes (DeltaCp) often accompany protein unfolding, protein binding, and specific DNA-ligand binding reactions. Such changes are widely used to analyze contributions arising from hydrophobic and polar hydration. Current models relate the magnitude of DeltaCp to the solvent accessible surface area (ASA) of the molecule. However, for many binding systems-particularly those involving non-peptide ligands-these models predict a DeltaCp that is significantly different from… CONTINUE READING

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