Electrostatic and non-electrostatic contributions to the binding free energies of anthracycline antibiotics to DNA.

Abstract

The knowledge about molecular factors driving simple ligand-DNA interactions is still limited. The aim of the present study was to investigate the electrostatic and non-electrostatic contributions to the binding free energies of anthracycline compounds with DNA. Theoretical calculations based on continuum methods (Poisson-Boltzmann and solvent accessible… (More)

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Cite this paper

@article{Baginski1997ElectrostaticAN, title={Electrostatic and non-electrostatic contributions to the binding free energies of anthracycline antibiotics to DNA.}, author={Maciej Baginski and Federico Fogolari and James Briggs}, journal={Journal of molecular biology}, year={1997}, volume={274 2}, pages={253-67} }