Electrostatic Modifications of the Human Leukocyte Antigen-DR P9 Peptide-Binding Pocket and Susceptibility to Primary Sclerosing Cholangitis

@inproceedings{Hov2011ElectrostaticMO,
  title={Electrostatic Modifications of the Human Leukocyte Antigen-DR P9 Peptide-Binding Pocket and Susceptibility to Primary Sclerosing Cholangitis},
  author={Johannes R Hov and Vasilis Kosmoliaptsis and James A Traherne and Marita Olsson and Kirsten Muri Boberg and Annika Bergquist and Erik Schrumpf and J Andrew Bradley and Craig J. Taylor and Benedicte Alexandra Lie and John Trowsdale and Tom H. Karlsen},
  booktitle={Hepatology},
  year={2011}
}
UNLABELLED The strongest genetic risk factors for primary sclerosing cholangitis (PSC) are found in the human leukocyte antigen (HLA) complex at chromosome 6p21. Genes in the HLA class II region encode molecules that present antigen to T lymphocytes. Polymorphisms in these genes are associated with most autoimmune diseases, most likely because they contribute to the specificity of immune responses. The aim of this study was to analyze the structure and electrostatic properties of the peptide… CONTINUE READING

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