Electrostatic Control and Chloride Regulation of the Fast Gating of ClC-0 Chloride Channels

  title={Electrostatic Control and Chloride Regulation of the Fast Gating of ClC-0 Chloride Channels},
  author={T Chen and Mei-fang Chen and Chia-Wei Lin},
  journal={The Journal of General Physiology},
  pages={641 - 651}
The opening and closing of chloride (Cl-) channels in the ClC family are thought to tightly couple to ion permeation through the channel pore. In the prototype channel of the family, the ClC-0 channel from the Torpedo electric organ, the opening-closing of the pore in the millisecond time range known as "fast gating" is regulated by both external and internal Cl- ions. Although the external Cl- effect on the fast-gate opening has been extensively studied at a quantitative level, the internal Cl… CONTINUE READING

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