Electrospun poly(hydroxybutyrate) scaffolds promote engraftment of human skin equivalents via macrophage M2 polarization and angiogenesis.

@article{Castellano2018ElectrospunPS,
  title={Electrospun poly(hydroxybutyrate) scaffolds promote engraftment of human skin equivalents via macrophage M2 polarization and angiogenesis.},
  author={Delia Castellano and Ana M Malabia Sanch{\'i}s and Mar{\'i}a Blanes and Mª Dolores P{\'e}rez Del Caz and A Ruiz-Sauri and Marina Piquer-Gil and Beatriz Pelacho and Bruno Di Marco and Nahuel Aquiles Garcia and Imelda Ontoria-Oviedo and Vicente Cambra and Felipe Pr{\'o}sper and Pilar Sep{\'u}lveda},
  journal={Journal of tissue engineering and regenerative medicine},
  year={2018},
  volume={12 2},
  pages={e983-e994}
}
Human dermo-epidermal skin equivalents (DE) comprising in vitro expanded autologous keratinocytes and fibroblasts are a good option for massive burn treatment. However, the lengthy expansion time required to obtain sufficient surface to cover an extensive burn together with the challenging surgical procedure limits their clinical use. The integration of DE and biodegradable scaffolds has been proposed in an effort to enhance their mechanical properties. Here, it is shown that poly… CONTINUE READING

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