Electrospun poly(ε-caprolactone)-based skin substitutes: In vivo evaluation of wound healing and the mechanism of cell proliferation.

@article{Augustine2015ElectrospunPS,
  title={Electrospun poly(ε-caprolactone)-based skin substitutes: In vivo evaluation of wound healing and the mechanism of cell proliferation.},
  author={Robin Augustine and Edwin Anto Dominic and Indu Reju and Balarama Kaimal and Nandakumar Kalarikkal and Sabu Thomas},
  journal={Journal of biomedical materials research. Part B, Applied biomaterials},
  year={2015},
  volume={103 7},
  pages={
          1445-54
        }
}
In the present study, we have fabricated electrospun poly(ε-caprolactone)-based membranes, characterized and studied the in vivo cell migration and proliferation and wound healing activity. Moreover, we did not seed any cells prior to the animal implantation and we could observe excellent fibroblast attachment and cell proliferation. Further full thickness excision wound on guinea pig completely healed within 35 days. We could reach in an assumption that the enhanced cell proliferation and… CONTINUE READING

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