Electrospray ionisation analysis of human fibrinogen.

  title={Electrospray ionisation analysis of human fibrinogen.},
  author={Stephen Brennan},
  journal={Thrombosis and haemostasis},
  volume={78 3},
Fibrinogen, a 340 kDa glycoprotein, was purified from human plasma, separated into its constituent polypeptide chains and analyzed by electrospray ionization mass spectrometry. Six individual plasmas were examined, and whilst the A alpha chain appeared homogeneous, the Bbeta and gamma chains were heterogeneous with the predominant form of each lacking a single sialic acid residue. The mean molecular masses of the dominant gamma and Bbeta isoforms were 48,366 and 54,200 Da with standard… CONTINUE READING


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