Electrospray-assisted laser desorption/ionization mass spectrometry for direct ambient analysis of solids.

@article{Shiea2005ElectrosprayassistedLD,
  title={Electrospray-assisted laser desorption/ionization mass spectrometry for direct ambient analysis of solids.},
  author={Jentaie Shiea and Min-Zon Huang and Hsiu-Jung Hsu and Chi-Yang Lee and Cheng-Hui Yuan and Iwona Beech and Jan Sunner},
  journal={Rapid communications in mass spectrometry : RCM},
  year={2005},
  volume={19 24},
  pages={
          3701-4
        }
}
A new method of electrospray-assisted laser desorption/ionization (ELDI) mass spectrometry, which combines laser desorption with post-ionization by electrospray, was applied to rapid analysis of solid materials under ambient conditions. Analytes were desorbed from solid metallic and insulating substrata using a pulsed nitrogen laser. Post-ionization produced high-quality mass spectra characteristic of electrospray, including protein multiple charging. For the first time, mass spectra of intact… CONTINUE READING
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