Electroporation-mediated pain-killer gene therapy for mononeuropathic rats

  title={Electroporation-mediated pain-killer gene therapy for mononeuropathic rats},
  author={C-R Lin and L Yang and T Lee and Chien-Te Lee and H-T Huang and W-Z Sun and J-t Cheng},
  journal={Gene Therapy},
The relatively low expression levels achieved from transferred genes have limited the application of nonviral vectors for gene transfer into the spinal cord in vivo. Thus, the aim of this study was to evaluate the efficacy of electroporation-mediated pro-opiomelanocortin (POMC) gene therapy for neuropathic pain using an animal model of chronic constrictive injury (CCI). Firstly, the optimal pulse characteristics (voltage, pulse duration, number of shocks) were investigated for in vivo… CONTINUE READING