Electroporation-induced damage in mammalian cell DNA.

  title={Electroporation-induced damage in mammalian cell DNA.},
  author={W S Meaking and Jeremy R. Edgerton and Christopher W Wharton and Rosalind A Meldrum},
  journal={Biochimica et biophysica acta},
  volume={1264 3},
Electroporation induced damage in the DNA of HL60 cells has been investigated by alkaline elution techniques. DNA damage is minimised by reducing the total charge applied (i.e., voltage x capacitance). Reduction of either of these electrical parameters, however, compromises the induced permeability of the cells to small molecules. The data presented… CONTINUE READING