Electroporation: theory and methods, perspectives for drug delivery, gene therapy and research.

  title={Electroporation: theory and methods, perspectives for drug delivery, gene therapy and research.},
  author={J. Gehl},
  journal={Acta physiologica Scandinavica},
  volume={177 4},
  • J. Gehl
  • Published 2003
  • Medicine
  • Acta physiologica Scandinavica
  • Electroporation designates the use of short high-voltage pulses to overcome the barrier of the cell membrane. By applying an external electric field, which just surpasses the capacitance of the cell membrane, transient and reversible breakdown of the membrane can be induced. This transient, permeabilized state can be used to load cells with a variety of different molecules, either through simple diffusion in the case of small molecules, or through electrophoretically driven processes allowing… CONTINUE READING
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