Electroporation: theory and methods, perspectives for drug delivery, gene therapy and research.

  title={Electroporation: theory and methods, perspectives for drug delivery, gene therapy and research.},
  author={J. Gehl},
  journal={Acta physiologica Scandinavica},
  volume={177 4},
  • J. Gehl
  • Published 2003
  • Medicine, Chemistry
  • Acta physiologica Scandinavica
  • Electroporation designates the use of short high-voltage pulses to overcome the barrier of the cell membrane. By applying an external electric field, which just surpasses the capacitance of the cell membrane, transient and reversible breakdown of the membrane can be induced. This transient, permeabilized state can be used to load cells with a variety of different molecules, either through simple diffusion in the case of small molecules, or through electrophoretically driven processes allowing… CONTINUE READING
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    Gene transfer into mouse lyoma cells by electroporation in high electric fields.
    • 2,045
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    Gene transfer into muscle by electroporation in vivo.
    • 902
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    Fundamentals of electroporative delivery of drugs and genes.
    • 371
    Theory and in vivo application of electroporative gene delivery.
    • 284
    Direct visualization at the single-cell level of electrically mediated gene delivery
    • 333
    • PDF
    In vivo electrically mediated protein and gene transfer in murine melanoma
    • 411