Electroporation: theory and methods, perspectives for drug delivery, gene therapy and research.

@article{Gehl2003ElectroporationTA,
  title={Electroporation: theory and methods, perspectives for drug delivery, gene therapy and research.},
  author={J. Gehl},
  journal={Acta physiologica Scandinavica},
  year={2003},
  volume={177 4},
  pages={
          437-47
        }
}
  • J. Gehl
  • Published 2003
  • Medicine
  • Acta physiologica Scandinavica
  • Electroporation designates the use of short high-voltage pulses to overcome the barrier of the cell membrane. By applying an external electric field, which just surpasses the capacitance of the cell membrane, transient and reversible breakdown of the membrane can be induced. This transient, permeabilized state can be used to load cells with a variety of different molecules, either through simple diffusion in the case of small molecules, or through electrophoretically driven processes allowing… CONTINUE READING
    707 Citations
    Electroporation Gene Therapy
    • 10
    In vivo gene expression: DNA electrotransfer.
    • 12
    Mechanism by which electroporation mediates DNA migration and entry into cells and targeted tissues.
    • M. Rols
    • Chemistry, Medicine
    • Methods in molecular biology
    • 2008
    • 42
    Modeling of electroporation mediated molecular delivery
    Dynamics and control of the two-pulse protocol in electroporation: numerical exploration.
    • 1
    • PDF

    References

    SHOWING 1-10 OF 103 REFERENCES
    Theory and in vivo application of electroporative gene delivery.
    • 286
    Fundamentals of electroporative delivery of drugs and genes.
    • 374
    Vascular reactions to in vivo electroporation: characterization and consequences for drug and gene delivery.
    • 190
    Direct visualization at the single-cell level of electrically mediated gene delivery
    • 336
    • PDF
    The importance of electric field distribution for effective in vivo electroporation of tissues.
    • 254
    • PDF
    Toxicity of anticancer agents mediated by electroporation in vitro
    • 128
    • Highly Influential
    Gene transfer into mouse lyoma cells by electroporation in high electric fields.
    • 2,061
    • PDF
    A syringe electrode device for simultaneous injection of DNA and electrotransfer.
    • F. Liu, L. Huang
    • Materials Science, Medicine
    • Molecular therapy : the journal of the American Society of Gene Therapy
    • 2002
    • 75