Electrophysiology of the neuroprotective agent riluzole on striatal spiny neurons.

  title={Electrophysiology of the neuroprotective agent riluzole on striatal spiny neurons.},
  author={Diego Centonze and Paolo Calabresi and Antonio Pisani and Silvia Marinelli and Girolama Alessandra Marfia and Giorgio Bernardi},
  volume={37 8},
Striatal spiny neurons are selectively vulnerable in Huntington's disease (HD). No effective treatment is available to limit neuronal death in this pathological condition. In an experimental model of HD, a beneficial effect has recently been reported by the neuroprotective agent riluzole. We performed intracellular recordings in order to characterize the electrophysiological effects of this compound on striatal spiny neurons. Riluzole (0.1-100 microM) affected neither the resting membrane… CONTINUE READING
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