Electrophysiology of the human colon: evidence of segmental heterogeneity.

  title={Electrophysiology of the human colon: evidence of segmental heterogeneity.},
  author={Geoffrey I. Sandle and Nancy K. Wills and W P Alles and Henry Joseph Binder},
  volume={27 9},
The electrical properties of epithelial cell membranes in human descending and ascending colon were studied using microelectrodes and the Na channel blocker amiloride. Under control (pre-amiloride) conditions, the transepithelial electrical measurements in the two colonic segments were similar. The mucosal addition of 0.1 mM amiloride to descending colon totally abolished the transepithelial voltage (Vt) and short-circuit current (Isc), and significantly increased the total tissue resistance… CONTINUE READING


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