Electrophysiology of lead intoxication: effects on voltage-sensitive ion channels.

  title={Electrophysiology of lead intoxication: effects on voltage-sensitive ion channels.},
  author={Gerald J. Audesirk},
  volume={14 2-3},
Neuronal function depends on the activity of a variety of voltage-sensitive, ion-specific membrane channels, including channels permeable chiefly to sodium, potassium, and calcium. The plasma membranes of many neurons contain several types of each class of channel. In general, heavy metal ions exert little effect on voltage-sensitive sodium or potassium channels, but inhibit ion flow through voltage-sensitive calcium channels (VSCC). The literature abounds with descriptions of different types… CONTINUE READING

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