Electrophysiology in the age of light

@article{Scanziani2009ElectrophysiologyIT,
  title={Electrophysiology in the age of light},
  author={Massimo Scanziani and Michael H{\"a}usser},
  journal={Nature},
  year={2009},
  volume={461},
  pages={930-939}
}
Electrophysiology, the 'gold standard' for investigating neuronal signalling, is being challenged by a new generation of optical probes. Together with new forms of microscopy, these probes allow us to measure and control neuronal signals with spatial resolution and genetic specificity that already greatly surpass those of electrophysiology. We predict that the photon will progressively replace the electron for probing neuronal function, particularly for targeted stimulation and silencing of… 

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