Electrophysiological properties of mutant Nav1.7 sodium channels in a painful inherited neuropathy.

@article{Cummins2004ElectrophysiologicalPO,
  title={Electrophysiological properties of mutant Nav1.7 sodium channels in a painful inherited neuropathy.},
  author={Theodore R. Cummins and Sulayman D. Dib-Hajj and Stephen G. Waxman},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2004},
  volume={24 38},
  pages={8232-6}
}
Although the physiological basis of erythermalgia, an autosomal dominant painful neuropathy characterized by redness of the skin and intermittent burning sensation of extremities, is not known, two mutations of Na(v)1.7, a sodium channel that produces a tetrodotoxin-sensitive, fast-inactivating current that is preferentially expressed in dorsal root ganglia (DRG) and sympathetic ganglia neurons, have recently been identified in patients with primary erythermalgia. Na(v)1.7 is preferentially… CONTINUE READING

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