Electrophysiological properties of axons in mice lacking neurofilament subunit genes: disparity between conduction velocity and axon diameter in absence of NF-H.

@article{Kriz2000ElectrophysiologicalPO,
  title={Electrophysiological properties of axons in mice lacking neurofilament subunit genes: disparity between conduction velocity and axon diameter in absence of NF-H.},
  author={Jasna Kriz and Qingjun Zhu and J. P. Julien and Ante L Padjen},
  journal={Brain research},
  year={2000},
  volume={885 1},
  pages={32-44}
}
Neurofilament proteins (NFs) are made by co-polymerization of three intermediate filament proteins, NF-L, NF-M and NF-H and constitute the most abundant cytoskeletal element in large myelinated axons. NFs have a well-established role as intrinsic determinants of axon caliber with all the functional implications, but the role of each individual NF subunit is much less clear. The aim of our study was to examine functional properties of large myelinated axons with altered morphology from mice… CONTINUE READING

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