Electrophysiological modelling of pulmonary artery smooth muscle cells in the rabbits--special consideration to the generation of hypoxic pulmonary vasoconstriction.

@article{Cha2008ElectrophysiologicalMO,
  title={Electrophysiological modelling of pulmonary artery smooth muscle cells in the rabbits--special consideration to the generation of hypoxic pulmonary vasoconstriction.},
  author={Chae Young Cha and Kee Hyun Earm and Jae Boum Youm and Eun Bok Baek and Sung Joon Kim and Yung E. Earm},
  journal={Progress in biophysics and molecular biology},
  year={2008},
  volume={96 1-3},
  pages={
          399-420
        }
}
In vascular smooth muscle cells, it has been suggested that membrane potential is an important component that initiates contraction. We developed a mathematical model to elucidate the quantitative contributions of major ion currents [a voltage-gated L-type Ca2+ current (ICaL), a voltage-sensitive K+ current (IKV), a Ca2+-activated K+ current (IKCa) and a nonselective cation current (INSC)] to membrane potential. In order to typify the diverse nature of pulmonary artery smooth muscle cells… CONTINUE READING

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Mathematical modelling of pulmonary arterial smooth muscle cell subtypes

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Hypoxia sensitivity of a voltage-gated potassium current in porcine intrapulmonary vein smooth muscle cells.

  • American journal of physiology. Lung cellular and molecular physiology
  • 2012
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Hypoxic pulmonary vasoconstriction.

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