Electrophysiological mechanisms of minoxidil sulfate-induced vasodilation of rabbit portal vein.

@article{Leblanc1989ElectrophysiologicalMO,
  title={Electrophysiological mechanisms of minoxidil sulfate-induced vasodilation of rabbit portal vein.},
  author={Normand Leblanc and D. J. Wilde and Kathleen D. Keef and Joseph R. Hume},
  journal={Circulation research},
  year={1989},
  volume={65 4},
  pages={1102-11}
}
The electrophysiological and mechanical properties of the vasodilator minoxidil sulfate (MNXS) were examined in isolated smooth muscle cells and strips from rabbit portal vein. At micromolar concentrations, MNXS inhibited norepinephrine (0.1-1.0 microM)-induced contractions in isolated muscle strips. In isolated cells, norepinephrine caused a dose-dependent depolarization of the resting membrane potential, which was significantly attenuated by MNXS (5 microM); MNXS alone caused a… CONTINUE READING

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