Electrophysiological measurements of a toad renal epithelial cell line (A6) as an assay to evaluate cellular toxicity in vitro.

Abstract

An established epithelial cell line (A6) from toad kidney was used to study in vitro cytotoxicity. When grown on permeable support, A6 cells form a monolayer epithelium with a high electrical resistance and a transepithelial potential. These two easily measured electrophysiological endpoints showed a dose-related decrease after exposure of the cells for 24… (More)

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