Electrophysiological heterogeneity and stability of reentry in simulated cardiac tissue.

@article{Xie2001ElectrophysiologicalHA,
  title={Electrophysiological heterogeneity and stability of reentry in simulated cardiac tissue.},
  author={Fagen Xie and Zhilin Qu and Alan Garfinkel and James N. Weiss},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2001},
  volume={280 2},
  pages={H535-45}
}
Generation of wave break is a characteristic feature of cardiac fibrillation. In this study, we investigated how dynamic factors and fixed electrophysiological heterogeneity interact to promote wave break in simulated two-dimensional cardiac tissue, by using the Luo-Rudy (LR1) ventricular action potential model. The degree of dynamic instability of the action potential model was controlled by varying the maximal amplitude of the slow inward Ca(2+) current to produce spiral waves in homogeneous… CONTINUE READING
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Visualization of stable intramural reentry during fibrillatory activity in perfused sheep right ventricle (Abstract)

AM Pertsov, SF Mironov, AZ Zaitsev, J. Jalife
Circulation 100, • 1999
View 4 Excerpts
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Preventing ventricular fibrillation by flattening cardiac restitution.

Proceedings of the National Academy of Sciences of the United States of America • 2000
View 3 Excerpts

Chaos and the transition to ventricular fibrillation: a new approach to antiarrhythmic drug

JN Weiss, A Garfinkel, HS Karagueuzian, ZL Qu, PS. Chen
evaluation. Circulation • 1999

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