Corpus ID: 30471500

Electrophysiological effects of tianeptine on rat locus coeruleus, raphe dorsalis, and hippocampus activity.

@article{Dresse1988ElectrophysiologicalEO,
  title={Electrophysiological effects of tianeptine on rat locus coeruleus, raphe dorsalis, and hippocampus activity.},
  author={A. Dresse and J. Scuv{\'e}e-Moreau},
  journal={Clinical neuropharmacology},
  year={1988},
  volume={11 Suppl 2},
  pages={
          S51-8
        }
}
Electrophysiological studies were performed in order to compare the influence of tianeptine and clomipramine on the firing rate of central locus coeruleus noradrenergic neurons, raphe dorsalis serotoninergic neurons, and hippocampus CA1 pyramidal cells. The interaction of tianeptine and clomipramine with the response of CA1 cells to iontophoretically applied 5-HT or GABA was also investigated. The i.v. perfusion of tianeptine decreased the firing rate of locus coeruleus neurons (ID50 = 1.74… Expand
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